Nano-patterned chip detects cancer in one blood drop
A research team led by researchers
from the University of Kansas and KU Cancer Center has developed a device which
could detect cancer in a minuscule amount of blood or blood component.
The device, which is
called a “3D nano-patterned chip”, identifies and diagnoses cancer by filtering
for exosomes, pushing them to meet the surface of the ship for analysis. Exosomes help in sending messages to the recipient
cells and communicating molecular information important in many biological
functions.
In the case of cancerous cells, these contain biological information
that can direct tumor growth and spread in case of cancerous cells.
Basically,
tumors send out exosomes packaging active molecules that mirror the biological
features of the parental cells. While all cells produce exosomes, tumor cells
are active compared to normal cells.
To test
the chip’s effectiveness, the researchers used clinical samples from patients
suffering from ovarian cancer, a type of cancer that is notoriously hard to detect.
They found that the chip was able to detect the presence of this cancer in even
the tiniest amount of blood plasma.
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