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A recent study has revealed that targeting tissues around pancreatic cancer cells may help stop their metastasis and improve chemotherapy outcomes. It was studied that how pancreatic cancer cells change their environment to enable easy metastasis, which is the main cause of pancreatic cancer-related death.
The researchers discovered that some pancreatic tumours remodel the environment around them, which helps cancer cells metastasize and protects them against chemotherapy.
Researchers compared tissue around tumour cells in both metastatic and non-metastatic pancreatic cancer cells. This tissue, known as matrix, acts like a glue that holds different cells or tumours together.
Using mouse models, the team extracted fibroblasts-cells that produce most of the matrix from both spreading and non-spreading pancreatic tumours. It was found that cancer cells from a non-spreading tumour began to spread when mixed with fibroblasts from a spreading tumour.
In this investigation, it was concluded that some pancreatic tumour cells instruct the fibroblasts to remodel the matrix and enhance the interaction with surrounding cells that supports cancer cells metastasize.



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