Immunotherapy drug effective against HPV-related cancers

-

According to a recent phase I clinical trial study, an investigational immunotherapy drug has shown effectiveness against tumors of advanced Human PapillomaVirus related cancers.

The drug, bintrafusp alfa, also called M7824, was designed to bind to two target proteins PD-L1 and TGF-beta simultaneously, that help prevent the immune system from effectively attacking tumours.The study included a total of 43 patients with advanced cancers, including cervical cancer, anal cancer and squamous cell carcinoma of head and neck.

Among all participants, 35% of the patients responded to the drug.

According to investigators, the drug is a promising agent for HPV-related cancers and may be beneficial more than traditional checkpoint therapies.

To know more, please visit: https://bit.ly/30LEfbU



Comments

Post a Comment

Popular posts from this blog

Nano-patterned chip detects cancer in one blood drop

-
Image
A research team led by researchers from the University of Kansas and KU Cancer Center has developed a device which could detect cancer in a minuscule amount of blood or blood component. The device, which is called a “3D nano-patterned chip”, identifies and diagnoses cancer by filtering for exosomes, pushing them to meet the surface of the ship for analysis. Exosomes help in sending messages to the  recipient cells and communicating molecular information important in many biological functions. In the case of cancerous cells, these contain biological information that can direct tumor growth and spread in case of cancerous cells. Basically, tumors send out exosomes packaging active molecules that mirror the biological features of the parental cells. While all cells produce exosomes, tumor cells are active compared to normal cells. To test the chip’s effectiveness, the researchers used clinical samples from patients suffering from ovarian cancer, a type of cancer ...
Read more
-
Image
A recent study has revealed that targeting tissues around pancreatic cancer cells may help stop their metastasis and improve chemotherapy outcomes. It was studied that how pancreatic cancer cells change their environment to enable easy metastasis, which is the main cause of pancreatic cancer-related death. The researchers discovered that some pancreatic tumours remodel the environment around them, which helps cancer cells metastasize and protects them against chemotherapy. Researchers compared tissue around tumour cells in both metastatic and non-metastatic pancreatic cancer cells. This tissue, known as matrix, acts like a glue that holds different cells or tumours together. Using mouse models, the team extracted fibroblasts-cells that produce most of the matrix from both spreading and non-spreading pancreatic tumours. It was found that cancer cells from a non-spreading tumour began to spread when mixed with fibroblasts from a spreading tumour. In this investigation, it was ...
Read more
-
Image
Recently, researchers investigated the microbiome of prostate fluid to know about the role of the microbiome in prostate cancer. Scientists carried out the first comprehensive and detailed comparison of the microbial ecosystems of prostatic fluid of people with and without prostate cancer. To investigate, they recruited 59 participants out of which, 32 people were prostate cancer patients and 27 people were without prostate cancer. It was found that they all had high levels of prostate-specific antigen (PSA), an enzyme secreted by the prostate. Prostate fluid samples taken from prostate cancer patients were found to be less diverse than the samples from men without cancer. Between the two groups, the researchers also measured differences in the proportions of certain species, including Enterobacter, Streptococcus and Lactococcus. However, at this stage, it is unclear that altered populations of bacteria influence the progression of prostate cancer. Measuring PSA Levels is ...
Read more