According to new studies, to spread in the other parts of the body, lung
cancer cells use antioxidants by activating protein BACH1 and increasing the
uptake and use of sugars.
It is a well-known fact
that cancer cells are exposed to oxidative stress caused by free oxygen
radicals. Also, cancer cells are characterized by high uptake and use of sugar.
When cancer cells metastasize to other parts of the body, they start reducing their
oxidative stress, which can happen in two ways: the cancer cells can either
obtain oxidants from the diet or synthesize their own.
In about one in every three cases
of lung cancer, the tumor cells have special mutations, linked to the NRF2 and
KEAP1 genes, which enable them to start producing their own antioxidants.
It is when the protein BACH1 is stabilized and
accumulates in the cancer cells.it stimulates metastasis mechanisms, including
one that orders the cancer cells to increase both the metabolism of sugar into
cell fuel and lactic acid, and the stockpiling of glucose from the blood
stream
Lung cancer is the leading cause of cancer-related
deaths worldwide. The most life-threatening aspect of lung cancer is metastasis.
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